| Gene Information | |
|---|---|
| Gene Name | GRL |
| Organism | Homo sapiens (Human) |
| Gene Length | 777 |
| Protein Names | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P04150 |
| Gene Card | NR3C1 |
| Uniprot ID | P04150 |
| Pfam | PF02155; PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803). {ECO:0000269|PubMed:10902803, ECO:0000269|PubMed:25847991}.; [Isoform Beta]: Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes. {ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; [Isoform Alpha-2]: Widely expressed. {ECO:0000269|PubMed:10566686}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001546(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1M2Z (X-ray 2.50A ) 1NHZ (X-ray 2.30A ) 1P93 (X-ray 2.70A ) 3BQD (X-ray 2.50A ) 3CLD (X-ray 2.84A ) 3E7C (X-ray 2.15A ) 3H52 (X-ray 2.80A ) 3K22 (X-ray 2.10A ) 3K23 (X-ray 3.00A ) 4CSJ (X-ray 2.30A ) 4HN5 (X-ray 1.90A ) 4HN6 (X-ray 2.55A ) 4LSJ (X-ray 2.35A ) 4MDD (X-ray 2.40A ) 4P6W (X-ray 1.95A ) 4P6X (X-ray 2.50A ) 4UDC (X-ray 2.50A ) 4UDD (X-ray 1.80A ) 5CBX (X-ray 2.00A ) 5CBY (X-ray 2.00A ) 5CBZ (X-ray 2.20A ) 5CC1 (X-ray 2.30A ) 5E69 (X-ray 1.85A ) 5E6A (X-ray 2.20A ) 5E6B (X-ray 2.25A ) 5E6C (X-ray 2.20A ) 5E6D (X-ray 2.40A ) 5EMC (X-ray 2.30A ) 5EMP (X-ray 2.30A ) 5EMQ (X-ray 2.30A ) 5G3J (X-ray 2.40A ) 5G5W (X-ray 2.20A ) 5NFP (X-ray 2.10A ) 5NFT (X-ray 2.30A ) 5UC3 (X-ray 2.01A ) 5VA0 (X-ray 2.29A ) 5VA7 (X-ray 2.15A ) 6BQU (X-ray 2.50A ) 6CFN (X-ray 2.50A ) 6DXK (X-ray 3.05A ) 6EL6 (X-ray 2.40A ) 6EL7 (X-ray 2.18A ) 6EL9 (X-ray 2.19A ) 6X6D (X-ray 2.48A ) 6X6E (X-ray 2.00A ) 6YMO (X-ray 2.02A ) 6YO8 (X-ray 2.09A ) 6YOS (X-ray 2.75A ) 7KRJ (EM 2.56A ) 7KW7 (EM 3.57A ) |
| DBSNP | rs6190 rs148102613 rs6192 rs542110718 rs1241576112 rs56149945 rs104893913 rs104893909 rs104893911 rs104893908 rs104893914 rs1027058734 rs121909727 rs104893910 rs121909726 rs104893912 |
| Subcellular location [CC] | [Isoform Alpha]: Cytoplasm {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}. Nucleus {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}. Mitochondrion {ECO:0000269|PubMed:21664385}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25847991}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25847991}. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628}.; [Isoform Beta]: Nucleus {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:8621628}. Cytoplasm {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253}. Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. {ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:26711253}.; [Isoform Alpha-B]: Nucleus {ECO:0000269|PubMed:15866175}. Cytoplasm {ECO:0000269|PubMed:15866175}. Note=After ligand activation, translocates from the cytoplasm to the nucleus. {ECO:0000269|PubMed:15866175}. |
| Mouse PG classification | NA |
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