| Gene Information | |
|---|---|
| Gene Name | GRK6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 576 |
| Protein Names | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000198055 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P43250 |
| Gene Card | GRK6 |
| Uniprot ID | P43250 |
| Pfam | PF00069; PF00615 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999723079) |
| Ortholog in Animals | Alpaca_ GRK6 ( ortholog_one2one ) Dog_ GRK6 ( ortholog_one2one ) GuineaPig_ GRK6 ( ortholog_one2one ) Macaque_ GRK6 ( ortholog_one2one ) Mouse_ Grk6 ( ortholog_one2one ) Pig_ GRK6 ( ortholog_one2one ) Rat_ Grk6 ( ortholog_one2one ) Rabbit_ GRK6 ( ortholog_one2one ) |
| Ohnologs | GRK5, GRK4 |
| Paralogs | RSKR, GRK7, GRK5, GRK1, GRK4, GRK3, GRK2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8415712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ACX (X-ray 2.60A ) 3NYN (X-ray 2.72A ) 3NYO (X-ray 2.92A ) |
| DBSNP | rs141014084 rs56382815 |
| Subcellular location [CC] | Membrane; Lipid-anchor. |
| Mouse PG classification | NA |
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