| Gene Information | |
|---|---|
| Gene Name | GRK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 590 |
| Protein Names | G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198873 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P34947 |
| Gene Card | GRK5 |
| Uniprot ID | P34947 |
| Pfam | PF00069; PF00615 |
| In ASD | no |
| Allosteric Prediction | yes (1.031819157) |
| Ortholog in Animals | Alpaca_ GRK5 ( ortholog_one2one ) Dog_ GRK5 ( ortholog_one2one ) GuineaPig_ GRK5 ( ortholog_one2one ) Macaque_ GRK5 ( ortholog_one2one ) Mouse_ Grk5 ( ortholog_one2one ) Pig_ GRK5 ( ortholog_one2one ) Rat_ Grk5 ( ortholog_one2one ) |
| Ohnologs | GRK4, GRK6 |
| Paralogs | RSKR, GRK7, GRK1, GRK4, GRK3, GRK6, GRK2 |
| Tissue | NA |
| Tissue Specificity | Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney. {ECO:0000269|PubMed:7685906}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4TNB (X-ray 2.11A ) 4TND (X-ray 1.80A ) 6PJX (X-ray 1.96A ) |
| DBSNP | rs2230345 rs55980792 rs55902633 rs34679178 rs56254855 rs2230349 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion. |
| Mouse PG classification | NA |
| click here to return to the previous page | |