| Gene Information | |
|---|---|
| Gene Name | GRK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 578 |
| Protein Names | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000125388 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P32298 |
| Gene Card | GRK4 |
| Uniprot ID | P32298 |
| Pfam | PF00069; PF00615 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000164225) |
| Ortholog in Animals | Alpaca_ GRK4 ( ortholog_one2one ) Dog_ GRK4 ( ortholog_one2one ) Mouse_ Grk4 ( ortholog_one2one ) Pig_ GRK4 ( ortholog_one2one ) Rat_ Grk4 ( ortholog_one2one ) Rabbit_ GRK4 ( ortholog_one2one ) |
| Ohnologs | GRK6, GRK5 |
| Paralogs | RSKR, GRK7, GRK5, GRK1, GRK3, GRK6, GRK2 |
| Tissue | testis |
| Tissue Specificity | Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269|PubMed:16636192, ECO:0000269|PubMed:8626439}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4YHJ (X-ray 2.60A ) |
| DBSNP | rs2960306 rs13305979 rs34857805 rs1024323 rs45538934 rs1140085 rs55852353 rs747003103 rs35024854 rs1801058 rs35463176 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells. |
| Mouse PG classification | NA |
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