| Gene Information | |
|---|---|
| Gene Name | GLIPR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 266 |
| Protein Names | Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1) |
| Target Name | glioma pathogenesis-related protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000139278 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48060 |
| Gene Card | GLIPR1 |
| Uniprot ID | P48060 |
| Pfam | PF00188 |
| In ASD | no |
| Allosteric Prediction | no (-0.757696907) |
| Ortholog in Animals | Alpaca_ GLIPR1 ( ortholog_one2one ) Dog_ GLIPR1 ( ortholog_one2one ) GuineaPig_ GLIPR1 ( ortholog_one2one ) Mouse_ Glipr1 ( ortholog_one2one ) Pig_ GLIPR1 ( ortholog_one2one ) Rat_ Glipr1 ( ortholog_one2one ) Rabbit_ GLIPR1 ( ortholog_one2one ) |
| Ohnologs | CRISP3, CRISPLD1, PI16 |
| Paralogs | CRISP2, CLEC18C, CLEC18A, CLEC18B, R3HDML, CRISPLD1, CRISP1, GLIPR1L1, GLIPR2, PI15, GLIPR1L2, CRISPLD2, CRISP3 |
| Tissue | NA |
| Tissue Specificity | According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3Q2R (X-ray 2.20A ) 3Q2U (X-ray 1.85A ) |
| DBSNP | rs28932170 rs3736392 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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