| Gene Information | |
|---|---|
| Gene Name | GRIN2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 1233 |
| Protein Names | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) |
| Target Name | glutamate receptor ionotropic nmda 2c |
| Target Type | Literature-reported target |
| Gene Age | 950 ( ENSG00000161509 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14957 |
| Gene Card | GRIN2C |
| Uniprot ID | Q14957 |
| Pfam | PF01094; PF00060; PF10613; PF10565 |
| In ASD | yes |
| Allosteric Prediction | yes (1.027567725) |
| Ortholog in Animals | Alpaca_ GRIN2C ( ortholog_one2one ) Dog_ GRIN2C ( ortholog_one2one ) GuineaPig_ GRIN2C ( ortholog_one2one ) Macaque_ GRIN2C ( ortholog_one2one ) Mouse_ Grin2c ( ortholog_one2one ) Pig_ GRIN2C ( ortholog_one2one ) Rat_ Grin2c ( ortholog_one2one ) |
| Ohnologs | GRIN2D, GRIN2A |
| Paralogs | GRIN3A, GRIN2A, GRIK5, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIA3, GRIK1, GRIA2, GRIA1, GRIN3B, GRIK2, GRIA4, GRIN2B |
| Tissue | cerebellum, cerebellar.hemisphere |
| Tissue Specificity | Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. {ECO:0000269|PubMed:9037519}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs192960268 rs201199917 rs746610735 rs1381530257 rs1308468356 rs765016248 rs139011774 rs370546831 rs960726960 rs552196496 rs889196426 rs751640851 rs115230539 rs143282101 rs3744215 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26875626}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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