| Gene Information | |
|---|---|
| Gene Name | GRIN2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1484 |
| Protein Names | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) |
| Target Name | glutamate receptor ionotropic, nmda 2b |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000273079 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13224 |
| Gene Card | GRIN2B |
| Uniprot ID | Q13224 |
| Pfam | PF01094; PF00060; PF10613; PF10565 |
| In ASD | yes |
| Allosteric Prediction | yes (1.597148751) |
| Ortholog in Animals | Alpaca_ GRIN2B ( ortholog_one2one ) Dog_ GRIN2B ( ortholog_one2one ) GuineaPig_ GRIN2B ( ortholog_one2one ) Macaque_ GRIN2B ( ortholog_one2one ) Mouse_ Grin2b ( ortholog_one2one ) Pig_ GRIN2B ( ortholog_one2one ) Rat_ Grin2b ( ortholog_one2one ) Rabbit_ GRIN2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GRIN3A, GRIN2A, GRIK5, GRIN2C, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIA3, GRIK1, GRIA2, GRIA1, GRIN3B, GRIK2, GRIA4 |
| Tissue | NA |
| Tissue Specificity | Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.287706(Rat);0.020000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5EWJ (X-ray 2.77A ) 5EWL (X-ray 2.98A ) 5EWM (X-ray 2.76A ) 7EU8 (EM 4.07A ) 7KL0 (X-ray 2.40A ) 7KL1 (X-ray 2.40A ) 7KL2 (X-ray 2.56A ) 7UIS (X-ray 2.58A ) 7UJP (X-ray 2.56A ) 7UJQ (X-ray 2.25A ) 7UJR (X-ray 1.95A ) 7UJS (X-ray 2.75A ) 7UJT (X-ray 2.10A ) |
| DBSNP | rs1057519553 rs201094029 rs138098032 rs527236034 rs1565478152 rs397514555 rs672601378 rs397514556 rs672601377 rs672601376 rs387906636 rs1555103971 rs797044849 rs201963596 rs201463390 rs748128078 rs758042475 rs756790727 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00960}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Late endosome {ECO:0000250|UniProtKB:Q01097}. Lysosome {ECO:0000250|UniProtKB:Q01097}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q01097}. Note=Co-localizes with the motor protein KIF17 along microtubules. {ECO:0000250|UniProtKB:Q01097}. |
| Mouse PG classification | LPG |
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