| Gene Information | |
|---|---|
| Gene Name | SYT11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 431 |
| Protein Names | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132718 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BT88 |
| Gene Card | SYT11 |
| Uniprot ID | Q9BT88 |
| Pfam | PF00168 |
| In ASD | no |
| Allosteric Prediction | yes (0.068478056) |
| Ortholog in Animals | Alpaca_ SYT11 ( ortholog_one2one ) Dog_ SYT11 ( ortholog_one2one ) GuineaPig_ SYT11 ( ortholog_one2one ) Macaque_ SYT11 ( ortholog_one2one ) Mouse_ Syt11 ( ortholog_one2one ) Pig_ SYT11 ( ortholog_one2one ) Rat_ Syt11 ( ortholog_one2one ) Rabbit_ SYT11 ( ortholog_one2one ) |
| Ohnologs | SYT4 |
| Paralogs | SYT2, SYTL3, SYT13, TC2N, SYT1, SYT7, SYTL4, SYTL5, DOC2B, DOC2A, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT4, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYTL2, SYT10, SYT5, SYT17 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs822522 rs17853892 |
| Subcellular location [CC] | Cytoplasmic vesicle membrane {ECO:0000305|PubMed:12925569}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9R0N3}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Lysosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9R0N3}. Cell projection, axon {ECO:0000269|PubMed:12925569}. Cell projection, dendrite {ECO:0000269|PubMed:12925569}. Postsynaptic density {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Perikaryon {ECO:0000269|PubMed:12925569}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity). Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients (PubMed:12925569). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:12925569}. |
| Mouse PG classification | NA |
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