| Gene Information | |
|---|---|
| Gene Name | GRIK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 908 |
| Protein Names | Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) |
| Target Name | glutamate receptor ionotropic, kainate 2 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000164418 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13002 |
| Gene Card | GRIK2 |
| Uniprot ID | Q13002 |
| Pfam | PF01094; PF00060; PF10613 |
| In ASD | yes |
| Allosteric Prediction | yes (1.335288199) |
| Ortholog in Animals | Alpaca_ GRIK2 ( ortholog_one2one ) Dog_ GRIK2 ( ortholog_one2one ) GuineaPig_ GRIK2 ( ortholog_one2one ) Macaque_ GRIK2 ( ortholog_one2one ) Mouse_ Grik2 ( ortholog_one2one ) Pig_ GRIK2 ( ortholog_one2one ) Rat_ Grik2 ( ortholog_one2one ) Rabbit_ GRIK2 ( ortholog_one2one ) |
| Ohnologs | GRIK5, GRIK4, GRIK1, GRIK3 |
| Paralogs | GRIN3A, GRIN2A, GRIK5, GRIN2C, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIA3, GRIK1, GRIA2, GRIA1, GRIN3B, GRIA4, GRIN2B |
| Tissue | brain, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expression is higher in cerebellum than in cerebral cortex. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003212(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3QXM (X-ray 1.65A ) 5CMM (X-ray 1.27A ) |
| DBSNP | rs1790057505 rs3213608 rs2235076 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:34375587}; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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