| Gene Information | |
|---|---|
| Gene Name | SH3GLB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000097033 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y371 |
| Gene Card | SH3GLB1 |
| Uniprot ID | Q9Y371 |
| Pfam | PF03114; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.329768032) |
| Ortholog in Animals | Alpaca_ SH3GLB1 ( ortholog_one2one ) Dog_ SH3GLB1 ( ortholog_one2one ) GuineaPig_ SH3GLB1 ( ortholog_one2one ) Macaque_ SH3GLB1 ( ortholog_one2one ) Mouse_ Sh3glb1 ( ortholog_one2one ) Pig_ SH3GLB1 ( ortholog_one2one ) Rat_ Sh3glb1 ( ortholog_one2one ) Rabbit_ SH3GLB1 ( ortholog_one2one ) |
| Ohnologs | SH3GLB2 |
| Paralogs | SH3GL3, SORBS1, SORBS2, SORBS3, SH3GLB2, NCF4, SH3RF3, SH3RF2, SH3GL1, SH3RF1, SH3D19, SH3GL2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11161816, ECO:0000269|PubMed:11259440}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6UP6 (EM 9.00A ) 6UPN (EM 10.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15452144}. Golgi apparatus membrane {ECO:0000269|PubMed:21068542}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:15452144}; Peripheral membrane protein {ECO:0000269|PubMed:15452144}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:17891140}. Midbody {ECO:0000269|PubMed:20643123}. Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140). {ECO:0000250, ECO:0000269|PubMed:17891140}. |
| Mouse PG classification | NA |
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