| Gene Information | |
|---|---|
| Gene Name | GRF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1499 |
| Protein Names | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NRY4 |
| Gene Card | ARHGAP35 |
| Uniprot ID | Q9NRY4 |
| Pfam | PF01846; PF00071; PF00620; PF16512; PF19518 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils (at protein level). {ECO:0000269|PubMed:1894621}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K85 (NMR - ) 3C5H (X-ray 1.80A ) 3FK2 (X-ray 2.80A ) 6PXC (X-ray 1.60A ) 6WAY (X-ray 1.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91YM2}. Cytoplasm {ECO:0000250|UniProtKB:Q91YM2}. Nucleus {ECO:0000305|PubMed:1894621}. Cell membrane {ECO:0000250|UniProtKB:Q91YM2}. Note=In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. {ECO:0000250|UniProtKB:Q91YM2}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |