| Gene Information | |
|---|---|
| Gene Name | GABRB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) |
| Target Name | gamma-aminobutyric acid receptor subunit beta-3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166206 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28472 |
| Gene Card | GABRB3 |
| Uniprot ID | P28472 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.375899776) |
| Ortholog in Animals | Alpaca_ GABRB3 ( ortholog_one2one ) Dog_ GABRB3 ( ortholog_one2one ) GuineaPig_ GABRB3 ( ortholog_one2one ) Macaque_ GABRB3 ( ortholog_one2one ) Mouse_ Gabrb3 ( ortholog_one2one ) Pig_ GABRB3 ( ortholog_one2one ) Rat_ Gabrb3 ( ortholog_one2one ) Rabbit_ GABRB3 ( ortholog_one2one ) |
| Ohnologs | GABRB2, GABRB1 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4COF (X-ray 2.97A ) 5O8F (X-ray 3.20A ) 5OJM (X-ray 3.30A ) 6A96 (EM 3.51A ) 6HUG (EM 3.10A ) 6HUJ (EM 3.04A ) 6HUK (EM 3.69A ) 6HUO (EM 3.26A ) 6HUP (EM 3.58A ) 6I53 (EM 3.20A ) 6QFA (EM 2.49A ) 7PBD (EM 3.04A ) 7PBZ (EM 2.79A ) 7PC0 (EM 3.00A ) 7QN5 (EM 2.50A ) 7QN6 (EM 2.90A ) 7QN7 (EM 3.00A ) 7QN8 (EM 3.10A ) 7QN9 (EM 2.90A ) 7QNA (EM 3.00A ) 7QNB (EM 3.10A ) 7QNC (EM 2.90A ) 7QND (EM 3.40A ) 7QNE (EM 2.70A ) |
| DBSNP | rs71651682 rs886037938 rs1057519550 rs17850679 rs886037939 rs121913125 rs797045045 rs886037940 rs1057519549 rs886037941 rs25409 rs121913126 |
| Subcellular location [CC] | Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:24909990}. Cell membrane {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:26950270}; Multi-pass membrane protein {ECO:0000269|PubMed:24909990}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}. |
| Mouse PG classification | NA |
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