| Gene Information | |
|---|---|
| Gene Name | GREM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 184 |
| Protein Names | Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) |
| Target Name | gremlin-1 |
| Target Type | Patented-recorded target |
| Gene Age | 810 ( ENSG00000166923 ) 3 ( ENSG00000276886 ) 3 ( ENSG00000282046 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60565 |
| Gene Card | GREM1 |
| Uniprot ID | O60565 |
| Pfam | PF03045 |
| In ASD | no |
| Allosteric Prediction | no (-0.969947249) |
| Ortholog in Animals | Alpaca_ GREM1 ( ortholog_one2one ) Dog_ GREM1 ( ortholog_one2one ) GuineaPig_ GREM1 ( ortholog_one2one ) Macaque_ GREM1 ( ortholog_one2one ) Mouse_ Grem1 ( ortholog_one2one ) Pig_ GREM1 ( ortholog_one2one ) Rat_ Grem1 ( ortholog_one2one ) Rabbit_ GREM1 ( ortholog_one2one ) |
| Ohnologs | GREM2 |
| Paralogs | GREM2, NBL1 |
| Tissue | ectocervix, endocervix, esophagus.muscularis.mucosa, gastroesophageal.junction, greater.omentum, sigmoid.colon, small.intestine.Peyers.patch, stomach, transverse.colon, vagina |
| Tissue Specificity | Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. {ECO:0000269|PubMed:10894942, ECO:0000269|PubMed:22561515}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5AEJ (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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