| Gene Information | |
|---|---|
| Gene Name | MLKL |
| Organism | Homo sapiens (Human) |
| Gene Length | 471 |
| Protein Names | Mixed lineage kinase domain-like protein (hMLKL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000168404 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NB16 |
| Gene Card | MLKL |
| Uniprot ID | Q8NB16 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.667478695) |
| Ortholog in Animals | Alpaca_ MLKL ( ortholog_one2one ) GuineaPig_ MLKL ( ortholog_one2one ) Macaque_ MLKL ( ortholog_one2one ) Mouse_ Mlkl ( ortholog_one2one ) Pig_ MLKL ( ortholog_one2one ) Rat_ Mlkl ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2MSV (NMR - ) 4M67 (X-ray 1.90A ) 4MWI (X-ray 1.70A ) 5KNJ (X-ray 2.88A ) 5KO1 (X-ray 2.16A ) 6BWK (X-ray 2.79A ) 6D74 (NMR - ) 6LK5 (X-ray 2.50A ) 6LK6 (X-ray 2.41A ) 6O5Z (X-ray 2.29A ) 6UX8 (X-ray 2.50A ) 6ZLE (NMR - ) 6ZPR (NMR - ) 6ZVO (X-ray 1.37A ) 6ZZ1 (X-ray 1.64A ) 7JW7 (X-ray 2.63A ) 7JXU (X-ray 2.44A ) 7MON (X-ray 2.23A ) 7NM2 (NMR - ) 7NM4 (NMR - ) 7NM5 (NMR - ) |
| DBSNP | rs34251827 rs33987771 rs35589326 rs34515646 rs55929310 rs1313508921 rs34389205 rs55987292 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. Nucleus {ECO:0000250|UniProtKB:Q9D2Y4}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:24316671}. |
| Mouse PG classification | NA |
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