| Gene Information | |
|---|---|
| Gene Name | GRB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 217 |
| Protein Names | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) |
| Target Name | grb2 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000177885 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P62993 |
| Gene Card | GRB2 |
| Uniprot ID | P62993 |
| Pfam | PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (1.146119782) |
| Ortholog in Animals | Alpaca_ GRB2 ( ortholog_one2one ) Dog_ GRB2 ( ortholog_one2one ) GuineaPig_ GRB2 ( ortholog_one2one ) Macaque_ GRB2 ( ortholog_one2one ) Mouse_ Grb2 ( ortholog_one2one ) Pig_ GRB2 ( ortholog_one2one ) Rat_ Grb2 ( ortholog_one2one ) Rabbit_ GRB2 ( ortholog_one2one ) |
| Ohnologs | GRAP |
| Paralogs | SLA, DAPP1, SH2D5, NCK1, GRAP, GRAPL, GRAP2, NCK2, SLA2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.318723(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1AZE (NMR - ) 1BM2 (X-ray 2.10A ) 1BMB (X-ray 1.80A ) 1CJ1 (X-ray 3.00A ) 1FHS (NMR - ) 1FYR (X-ray 2.40A ) 1GCQ (X-ray 1.68A ) 1GFC (NMR - ) 1GFD (NMR - ) 1GHU (NMR - ) 1GRI (X-ray 3.10A ) 1IO6 (NMR - ) 1JYQ (X-ray 2.00A ) 1JYR (X-ray 1.55A ) 1JYU (X-ray 2.75A ) 1QG1 (NMR - ) 1TZE (X-ray 2.10A ) 1X0N (NMR - ) 1ZFP (X-ray 1.80A ) 2AOA (X-ray 1.99A ) 2AOB (X-ray 1.80A ) 2H46 (X-ray 1.90A ) 2H5K (X-ray 3.25A ) 2HUW (X-ray 1.90A ) 2VVK (X-ray 1.60A ) 2VWF (X-ray 1.58A ) 2W0Z (X-ray 1.70A ) 3C7I (X-ray 1.70A ) 3IMD (X-ray 2.00A ) 3IMJ (X-ray 2.02A ) 3IN7 (X-ray 2.00A ) 3IN8 (X-ray 1.70A ) 3KFJ (X-ray 2.02A ) 3MXC (X-ray 2.00A ) 3MXY (X-ray 2.30A ) 3N7Y (X-ray 2.02A ) 3N84 (X-ray 2.00A ) 3N8M (X-ray 2.00A ) 3OV1 (X-ray 1.60A ) 3OVE (X-ray 1.82A ) 3S8L (X-ray 1.71A ) 3S8N (X-ray 1.71A ) 3S8O (X-ray 1.85A ) 3WA4 (X-ray 1.35A ) 4P9V (X-ray 1.64A ) 4P9Z (X-ray 1.80A ) 5CDW (X-ray 2.60A ) 6ICG (X-ray 1.15A ) 6ICH (X-ray 2.00A ) 6SDF (X-ray 2.50A ) 6VK2 (NMR - ) 6WM1 (X-ray 1.80A ) 6WO2 (X-ray 2.00A ) 7MPH (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}. |
| Mouse PG classification | NA |
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