| Gene Information | |
|---|---|
| Gene Name | GRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 724 |
| Protein Names | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P27986 |
| Gene Card | PIK3R1 |
| Uniprot ID | P27986 |
| Pfam | PF16454; PF00620; PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). {ECO:0000269|PubMed:8628286}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.318826(Rat);0.108948(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A0N (NMR - ) 1AZG (NMR - ) 1H9O (X-ray 1.79A ) 1PBW (X-ray 2.00A ) 1PHT (X-ray 2.00A ) 1PIC (NMR - ) 1PKS (NMR - ) 1PKT (NMR - ) 2IUG (X-ray 1.89A ) 2IUH (X-ray 2.00A ) 2IUI (X-ray 2.40A ) 2RD0 (X-ray 3.05A ) 2V1Y (X-ray 2.40A ) 3HHM (X-ray 2.80A ) 3HIZ (X-ray 3.30A ) 3I5R (X-ray 1.70A ) 3I5S (X-ray 3.00A ) 4A55 (X-ray 3.50A ) 4JPS (X-ray 2.20A ) 4L1B (X-ray 2.59A ) 4L23 (X-ray 2.50A ) 4L2Y (X-ray 2.80A ) 4OVU (X-ray 2.96A ) 4OVV (X-ray 3.50A ) 4WAF (X-ray 2.39A ) 4YKN (X-ray 2.90A ) 4ZOP (X-ray 2.62A ) 5AUL (X-ray 1.10A ) 5FI4 (X-ray 2.50A ) 5GJI (X-ray 0.90A ) 5ITD (X-ray 3.02A ) 5M6U (X-ray 2.85A ) 5SW8 (X-ray 3.30A ) 5SWG (X-ray 3.11A ) 5SWO (X-ray 3.50A ) 5SWP (X-ray 3.41A ) 5SWR (X-ray 3.31A ) 5SWT (X-ray 3.49A ) 5SX8 (X-ray 3.47A ) 5SX9 (X-ray 3.52A ) 5SXA (X-ray 3.35A ) 5SXB (X-ray 3.30A ) 5SXC (X-ray 3.55A ) 5SXD (X-ray 3.50A ) 5SXE (X-ray 3.51A ) 5SXF (X-ray 3.46A ) 5SXI (X-ray 3.40A ) 5SXJ (X-ray 3.42A ) 5SXK (X-ray 3.55A ) 5UBT (X-ray 2.83A ) 5UK8 (X-ray 2.50A ) 5UKJ (X-ray 2.80A ) 5UL1 (X-ray 3.00A ) 5VLR (X-ray 2.80A ) 5XGH (X-ray 2.97A ) 5XGI (X-ray 2.56A ) 5XGJ (X-ray 2.97A ) 6NCT (X-ray 3.35A ) 6PYR (X-ray 2.21A ) 6PYU (X-ray 2.54A ) 7CIO (X-ray 1.10A ) 7LM2 (X-ray 2.79A ) 7LQ1 (X-ray 2.96A ) 7MYN (EM 2.79A ) 7MYO (EM 2.92A ) 7PG5 (X-ray 2.20A ) 7PG6 (X-ray 2.50A ) 7RNS (X-ray 1.14A ) 7TZ7 (X-ray 2.41A ) |
| DBSNP | rs3730089 rs748784250 rs17852841 rs397514047 rs397515453 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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