| Gene Information | |
|---|---|
| Gene Name | GRAMD2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 354 |
| Protein Names | GRAM domain-containing protein 2A |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000175318 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IUY3 |
| Gene Card | GRAMD2A |
| Uniprot ID | Q8IUY3 |
| Pfam | PF02893 |
| In ASD | no |
| Allosteric Prediction | no (-1.594804095) |
| Ortholog in Animals | Alpaca_ GRAMD2A ( ortholog_one2one ) Dog_ GRAMD2A ( ortholog_one2one ) GuineaPig_ GRAMD2A ( ortholog_one2one ) Macaque_ GRAMD2A ( ortholog_one2one ) Mouse_ Gramd2 ( ortholog_one2one ) Rat_ Gramd2a ( ortholog_one2one ) Rabbit_ GRAMD2A ( ortholog_one2one ) |
| Ohnologs | GRAMD2B |
| Paralogs | GRAMD1A, GRAMD1C, GRAMD1B, GRAMD2B |
| Tissue | placenta, lung |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:29469807}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A. {ECO:0000269|PubMed:29469807}. |
| Mouse PG classification | NA |
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