| Gene Information | |
|---|---|
| Gene Name | DENND4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1863 |
| Protein Names | C-myc promoter-binding protein (DENN domain-containing protein 4A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000174485 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z401 |
| Gene Card | DENND4A |
| Uniprot ID | Q7Z401 |
| Pfam | PF03455; PF02141; PF03456 |
| In ASD | no |
| Allosteric Prediction | no (-0.89762931) |
| Ortholog in Animals | Alpaca_ DENND4A ( ortholog_one2one ) Dog_ DENND4A ( ortholog_one2one ) GuineaPig_ DENND4A ( ortholog_one2one ) Macaque_ DENND4A ( ortholog_one2one ) Mouse_ Dennd4a ( ortholog_one2one ) Pig_ DENND4A ( ortholog_one2one ) Rat_ Dennd4a ( ortholog_one2one ) Rabbit_ DENND4A ( ortholog_one2one ) |
| Ohnologs | DENND4C, DENND4B |
| Paralogs | DENND3, DENND4C, DENND4B |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. {ECO:0000269|PubMed:12906859}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17854146 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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