| Gene Information | |
|---|---|
| Gene Name | GPSM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 684 |
| Protein Names | G-protein-signaling modulator 2 (Mosaic protein LGN) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000121957 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P81274 |
| Gene Card | GPSM2 |
| Uniprot ID | P81274 |
| Pfam | PF02188; PF13176; PF13181 |
| In ASD | no |
| Allosteric Prediction | yes (0.347711059) |
| Ortholog in Animals | Alpaca_ GPSM2 ( ortholog_one2one ) Dog_ GPSM2 ( ortholog_one2many ) Macaque_ GPSM2 ( ortholog_one2one ) Mouse_ Gpsm2 ( ortholog_one2one ) Pig_ GPSM2 ( ortholog_one2one ) Rat_ Gpsm2 ( ortholog_one2one ) Rabbit_ GPSM2 ( ortholog_one2one ) |
| Ohnologs | GPSM1 |
| Paralogs | GPSM1, TTC28, RAPSN, GPSM3, TTC24, TTC29 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.133333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SF4 (X-ray 2.60A ) 4WND (X-ray 1.50A ) 4WNE (X-ray 2.00A ) 4WNF (X-ray 2.90A ) 4WNG (X-ray 2.11A ) 5A6C (X-ray 2.90A ) 6HC2 (X-ray 4.31A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:22074847}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22074847, ECO:0000269|PubMed:22327364}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:21816348}. Lateral cell membrane {ECO:0000269|PubMed:26766442}. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase (PubMed:11781568, PubMed:15632202, PubMed:22074847). Colocalizes with NUMA1 to mitotic spindle poles (PubMed:11781568, PubMed:21816348). Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (PubMed:22327364). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region. In vertically retinal progenitor dividing cells, localized at the polar cortical region (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22074847, ECO:0000269|PubMed:22327364}. |
| Mouse PG classification | NA |
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