| Gene Information | |
|---|---|
| Gene Name | GPS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 327 |
| Protein Names | G protein pathway suppressor 2 (GPS-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000132522 ) 3 ( ENSG00000288325 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13227 |
| Gene Card | GPS2 |
| Uniprot ID | Q13227 |
| Pfam | PF15991 |
| In ASD | no |
| Allosteric Prediction | no (-0.289847083) |
| Ortholog in Animals | Alpaca_ GPS2 ( ortholog_one2one ) Dog_ GPS2 ( ortholog_one2one ) GuineaPig_ GPS2 ( ortholog_one2one ) Macaque_ GPS2 ( ortholog_one2one ) Mouse_ Gps2 ( ortholog_one2one ) Pig_ GPS2 ( ortholog_one2one ) Rat_ Gps2 ( ortholog_one2one ) Rabbit_ GPS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8943324}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L5G (NMR - ) |
| DBSNP | rs2292065 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19858209, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:29499132}. Mitochondrion {ECO:0000269|PubMed:29499132}. Cytoplasm, cytosol {ECO:0000269|PubMed:24223774, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:29499132}. Note=Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity). {ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:24943844}. |
| Mouse PG classification | NA |
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