| Gene Information | |
|---|---|
| Gene Name | GPRC6A |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33) |
| Target Name | g-protein coupled receptor gpcr33 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000173612 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5T6X5 |
| Gene Card | GPRC6A |
| Uniprot ID | Q5T6X5 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.354063333) |
| Ortholog in Animals | Alpaca_ GPRC6A ( ortholog_one2one ) Dog_ GPRC6A ( ortholog_one2one ) Macaque_ GPRC6A ( ortholog_one2one ) Mouse_ Gprc6a ( ortholog_one2one ) Pig_ GPRC6A ( ortholog_one2one ) Rat_ Gprc6a ( ortholog_one2one ) Rabbit_ GPRC6A ( ortholog_one2one ) |
| Ohnologs | CASR, TAS1R2 |
| Paralogs | TAS1R3, TAS1R1, TAS1R2, CASR |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. {ECO:0000269|PubMed:15194188}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2274911 rs28360548 rs35937022 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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