| Gene Information | |
|---|---|
| Gene Name | GPRC5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 357 |
| Protein Names | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) |
| Target Name | retinoic acid-induced protein 3 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000013588 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NFJ5 |
| Gene Card | GPRC5A |
| Uniprot ID | Q8NFJ5 |
| Pfam | PF00003 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000216226) |
| Ortholog in Animals | Alpaca_ GPRC5A ( ortholog_one2one ) Dog_ GPRC5A ( ortholog_one2one ) GuineaPig_ GPRC5A ( ortholog_one2one ) Macaque_ GPRC5A ( ortholog_one2one ) Mouse_ Gprc5a ( ortholog_one2one ) Pig_ GPRC5A ( ortholog_one2one ) Rat_ Gprc5a ( ortholog_one2one ) Rabbit_ GPRC5A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPRC5D, GPRC5B, GPRC5C |
| Tissue | lung |
| Tissue Specificity | Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal cord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. {ECO:0000269|PubMed:10783259, ECO:0000269|PubMed:10945465, ECO:0000269|PubMed:18000218, ECO:0000269|PubMed:9857033}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11550683 rs850932 rs12368599 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269|PubMed:18000218}. |
| Mouse PG classification | NA |
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