| Gene Information | |
|---|---|
| Gene Name | GPRC3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 961 |
| Protein Names | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UBS5 |
| Gene Card | GABBR1 |
| Uniprot ID | Q9UBS5 |
| Pfam | PF00003; PF01094; PF00084 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain (PubMed:9844003, PubMed:9753614, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333). {ECO:0000269|PubMed:10906333, ECO:0000269|PubMed:9753614, ECO:0000269|PubMed:9844003, ECO:0000269|PubMed:9872744}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4MQE (X-ray 2.35A ) 4MQF (X-ray 2.22A ) 4MR7 (X-ray 2.15A ) 4MR8 (X-ray 2.15A ) 4MR9 (X-ray 2.35A ) 4MRM (X-ray 2.86A ) 4MS1 (X-ray 2.25A ) 4MS3 (X-ray 2.50A ) 4MS4 (X-ray 1.90A ) 4PAS (X-ray 1.62A ) 6HKC (NMR - ) 6UO8 (EM 3.63A ) 6UO9 (EM 4.80A ) 6UOA (EM 6.30A ) 6VJM (EM 3.97A ) 6W2X (EM 3.60A ) 6W2Y (EM 3.20A ) 6WIV (EM 3.30A ) 7C7Q (EM 3.00A ) 7C7S (EM 2.90A ) 7CA3 (EM 4.50A ) 7CA5 (EM 7.60A ) 7CUM (EM 3.52A ) 7EB2 (EM 3.50A ) |
| DBSNP | rs1805056 rs1805057 rs2076489 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15617512}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9Z0U4}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z0U4}. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:15617512}.; [Isoform 1E]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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