Gene Information
Gene NameDES
OrganismHomo sapiens (Human)
Gene Length470
Protein NamesDesmin
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000175084 )
Evolutionary StageEukaryota
AlphaFoldDBP17661
Gene CardDES
Uniprot IDP17661
PfamPF00038; PF04732
In ASDno
Allosteric Predictionyes (0.115499162)
Ortholog in AnimalsAlpaca_ DES ( ortholog_one2one )
Dog_ DES ( ortholog_one2one )
GuineaPig_ DES ( ortholog_one2one )
Macaque_ DES ( ortholog_one2one )
Mouse_ Des ( ortholog_one2one )
Pig_ DES ( ortholog_one2one )
Rat_ Des ( ortholog_one2one )
Rabbit_ DES ( ortholog_one2one )
OhnologsKRT33A, VIM, NEFH, NEFM, KRT18, GFAP, PRPH, KRT7, KRT84, KRT82, KRT80, KRT1, KRT8, KRT86, KRT75, KRT6C, KRT4, KRT83, KRT19, KRT15, KRT2, KRT6B, KRT79, KRT5, KRT10, KRT17P2, KRT16, KRT14, KRT77, KRT6A
ParalogsVIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs58999456  rs903985237  rs62636495  rs60798368  rs60794845  rs60794845  rs267607499  rs1954373010  rs397516695  rs41272699  rs201945924  rs267607486  rs59962885  rs57496341  rs267607482  rs57639980  rs57965306  rs61368398  rs58898021  rs121913000  rs59308628  rs57955682  rs121913004  rs121913001  rs61130669  rs57694264  rs121913003  rs62635763  rs121913005  rs267607485  rs121913002  rs267607488  rs267607490  rs267607491 
Subcellular location [CC]Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:26724190, ECO:0000269|PubMed:30262925}. Cytoplasm {ECO:0000269|PubMed:25394388}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25394388}. Nucleus {ECO:0000250|UniProtKB:P31001}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:26724190}.
Mouse PG classificationHPG
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