| Gene Information | |
|---|---|
| Gene Name | KLRC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 233 |
| Protein Names | NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a) |
| Target Name | nkg2-a/b-activating nk receptor |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000134545 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P26715 |
| Gene Card | KLRC1 |
| Uniprot ID | P26715 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.790596586) |
| Ortholog in Animals | Alpaca_ KLRC1 ( ortholog_one2one ) Mouse_ Klrc2 ( ortholog_many2many ) Mouse_ Klrc3 ( ortholog_many2many ) Mouse_ Klrc1 ( ortholog_many2many ) Mouse_ Klrh1 ( ortholog_many2many ) Mouse_ Clec2m ( ortholog_many2many ) Mouse_ Klri1 ( ortholog_many2many ) Mouse_ Klri2 ( ortholog_many2many ) Mouse_ Klre1 ( ortholog_many2many ) Rat_ Klrc1 ( ortholog_many2many ) Rat_ Klrc3 ( ortholog_many2many ) Rat_ Klrh1 ( ortholog_many2many ) Rat_ RGD1564770 ( ortholog_many2many ) Rat_ Klri1 ( ortholog_many2many ) Rat_ Klri2 ( ortholog_many2many ) Rat_ Klre1 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A, KLRB1 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in NK cells (at protein level) (PubMed:9430220, PubMed:9485206, PubMed:20952657). Expressed in intraepithelial CD8-positive T cell subsets with higher frequency in gamma-delta T cells than alpha-beta T cells (at protein level) (PubMed:18064301). Expressed in memory gamma-delta T cells (at protein level) (PubMed:20952657). Restricted to a subset of memory/effector CD8-positive alpha-beta T cells (at protein level) (PubMed:12387742). Expressed in intratumoral NK and CD8-positive T cells (PubMed:30503213). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657). {ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2RMX (NMR - ) 2YU7 (NMR - ) 3BDW (X-ray 2.50A ) 3CDG (X-ray 3.40A ) 3CII (X-ray 4.41A ) |
| DBSNP | rs2253849 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:20952657}; Single-pass type II membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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