| Gene Information | |
|---|---|
| Gene Name | GPR51 |
| Organism | Homo sapiens (Human) |
| Gene Length | 941 |
| Protein Names | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75899 |
| Gene Card | GABBR2 |
| Uniprot ID | O75899 |
| Pfam | PF00003; PF01094; PF18455 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622). {ECO:0000269|PubMed:10087195, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:10727622, ECO:0000269|PubMed:9872744}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4F11 (X-ray 2.38A ) 4F12 (X-ray 3.02A ) 4MQE (X-ray 2.35A ) 4MQF (X-ray 2.22A ) 4MR7 (X-ray 2.15A ) 4MR8 (X-ray 2.15A ) 4MR9 (X-ray 2.35A ) 4MRM (X-ray 2.86A ) 4MS1 (X-ray 2.25A ) 4MS3 (X-ray 2.50A ) 4MS4 (X-ray 1.90A ) 4PAS (X-ray 1.62A ) 6M8R (X-ray 3.20A ) 6OCP (X-ray 2.35A ) 6UO8 (EM 3.63A ) 6UO9 (EM 4.80A ) 6UOA (EM 6.30A ) 6VJM (EM 3.97A ) 6W2X (EM 3.60A ) 6WIV (EM 3.30A ) 7C7Q (EM 3.00A ) 7C7S (EM 2.90A ) 7CA3 (EM 4.50A ) 7CA5 (EM 7.60A ) 7CUM (EM 3.52A ) 7EB2 (EM 3.50A ) |
| DBSNP | rs35449008 rs922847767 rs1554689320 rs1554689319 rs1554689315 rs1554689313 rs10985765 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:9872316}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O88871}; Multi-pass membrane protein {ECO:0000305}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. {ECO:0000269|PubMed:15617512}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |