| Gene Information | |
|---|---|
| Gene Name | HCRTR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) |
| Target Name | orexin receptor type 2 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000137252 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43614 |
| Gene Card | HCRTR2 |
| Uniprot ID | O43614 |
| Pfam | PF00001; PF03827 |
| In ASD | no |
| Allosteric Prediction | yes (0.880472004) |
| Ortholog in Animals | Alpaca_ HCRTR2 ( ortholog_one2one ) Dog_ HCRTR2 ( ortholog_one2one ) GuineaPig_ HCRTR2 ( ortholog_one2one ) Macaque_ HCRTR2 ( ortholog_one2one ) Mouse_ Hcrtr2 ( ortholog_one2one ) Pig_ HCRTR2 ( ortholog_one2one ) Rat_ Hcrtr2 ( ortholog_one2one ) Rabbit_ HCRTR2 ( ortholog_one2one ) |
| Ohnologs | GPR83, HCRTR1 |
| Paralogs | HCRTR1, NPFFR1, NPFFR2, CCKBR, CCKAR, OXTR, AVPR2, AVPR1B, AVPR1A, GNRHR, GALR3, GPR22, GPR150, FFAR4, GALR1, QRFPR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4S0V (X-ray 2.50A ) 5WQC (X-ray 1.96A ) 5WS3 (X-ray 2.30A ) 6TPG (X-ray 2.74A ) 6TPJ (X-ray 2.74A ) 6TPN (X-ray 2.61A ) 7L1U (EM 3.20A ) 7L1V (EM 3.00A ) 7SQO (EM 3.17A ) |
| DBSNP | rs41271310 rs41271312 rs74720027 rs2653349 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897, ECO:0000305|PubMed:25533960}; Multi-pass membrane protein {ECO:0000269|PubMed:25533960}. |
| Mouse PG classification | NA |
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