| Gene Information | |
|---|---|
| Gene Name | GPR35 |
| Organism | Homo sapiens (Human) |
| Gene Length | 309 |
| Protein Names | G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor) |
| Target Name | g-protein coupled receptor 35 |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000178623 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9HC97 |
| Gene Card | GPR35 |
| Uniprot ID | Q9HC97 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.321304541) |
| Ortholog in Animals | Alpaca_ GPR35 ( ortholog_one2one ) GuineaPig_ GPR35 ( ortholog_one2one ) Macaque_ GPR35 ( ortholog_one2one ) Mouse_ Gpr35 ( ortholog_one2one ) Pig_ GPR35 ( ortholog_one2one ) Rat_ Gpr35 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | F2RL2, P2RY8, F2RL1, F2R, F2RL3, GPR18, GPR65, CYSLTR2, GPR17, GPR4, CYSLTR1, GPR20, GPR55, LPAR4, LPAR6, P2RY10 |
| Tissue | colon, duodenum, small.intestine, stomach, gall.bladder |
| Tissue Specificity | Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269|PubMed:16754668}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35146537 rs139197368 rs13387859 rs3749171 rs34778053 rs12468485 rs3749172 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16754668}; Multi-pass membrane protein {ECO:0000269|PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid. |
| Mouse PG classification | NA |
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