| Gene Information | |
|---|---|
| Gene Name | GPR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 330 |
| Protein Names | G-protein coupled receptor 3 (ACCA orphan receptor) |
| Target Name | g protein-coupled receptor 3 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000181773 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P46089 |
| Gene Card | GPR3 |
| Uniprot ID | P46089 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.524417665) |
| Ortholog in Animals | Alpaca_ GPR3 ( ortholog_one2one ) Dog_ GPR3 ( ortholog_one2one ) GuineaPig_ GPR3 ( ortholog_one2one ) Macaque_ GPR3 ( ortholog_one2one ) Mouse_ Gpr3 ( ortholog_one2one ) Pig_ GPR3 ( ortholog_one2one ) Rat_ Gpr3 ( ortholog_one2one ) Rabbit_ GPR3 ( ortholog_one2one ) |
| Ohnologs | LPAR2, MC3R, GPR12, GPR6, S1PR1, LPAR3 |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, MC5R, MC1R, MC2R, MC3R, MC4R, GPR6, GPR12, GPR119, CNR1, CNR2 |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs734852 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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