Gene Information
Gene NameETS1
OrganismHomo sapiens (Human)
Gene Length441
Protein NamesProtein C-ets-1 (p54)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000134954 )
Evolutionary StageEumetazoa
AlphaFoldDBP14921
Gene CardETS1
Uniprot IDP14921
PfamPF00178; PF19525; PF02198
In ASDyes
Allosteric Predictionyes (0.999939909)
Ortholog in AnimalsAlpaca_ ETS1 ( ortholog_one2one )
Dog_ ETS1 ( ortholog_one2one )
GuineaPig_ ETS1 ( ortholog_one2one )
Macaque_ ETS1 ( ortholog_one2one )
Mouse_ Ets1 ( ortholog_one2one )
Pig_ ETS1 ( ortholog_one2one )
Rat_ Ets1 ( ortholog_one2one )
Rabbit_ c-ets-1 ( ortholog_one2one )
OhnologsETS2
ParalogsELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ELF2, SPI1, ELK4, ELF1, SPIB, FEV, SPIC, ERFL, SPDEF
TissueNA
Tissue SpecificityHighly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269|PubMed:19377509, ECO:0000269|PubMed:20378371}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GVJ  (X-ray  1.53A  2NNY  (X-ray  2.58A  2STT  (NMR  2STW  (NMR  3MFK  (X-ray  3.00A  3RI4  (X-ray  3.00A  3WTS  (X-ray  2.35A  3WTT  (X-ray  2.35A  3WTU  (X-ray  2.70A  3WTV  (X-ray  2.70A  3WTW  (X-ray  2.90A  3WTX  (X-ray  2.80A  3WTY  (X-ray  2.70A  3WTZ  (X-ray  2.61A  3WU0  (X-ray  2.60A  3WU1  (X-ray  2.40A  4L0Y  (X-ray  2.50A  4L0Z  (X-ray  2.70A  4L18  (X-ray  2.30A  4LG0  (X-ray  2.19A  5ZMC  (X-ray  2.99A 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:19377509}. Cytoplasm {ECO:0000269|PubMed:19377509}. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269|PubMed:19377509}.
Mouse PG classificationNA
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