Gene Information
Gene NameKNSTRN
OrganismHomo sapiens (Human)
Gene Length316
Protein NamesSmall kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000128944 )
Evolutionary StageVertebrata
AlphaFoldDBQ9Y448
Gene CardKNSTRN
Uniprot IDQ9Y448
PfamNA
In ASDno
Allosteric Predictionno (-1.574803398)
Ortholog in AnimalsAlpaca_ KNSTRN ( ortholog_one2one )
GuineaPig_ KNSTRN ( ortholog_one2one )
Macaque_ KNSTRN ( ortholog_one2one )
Mouse_ Knstrn ( ortholog_one2one )
Pig_ KNSTRN ( ortholog_one2one )
Rat_ Knstrn ( ortholog_one2one )
Rabbit_ KNSTRN ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuetestis
Tissue SpecificityWidely expressed, including in skin. {ECO:0000269|PubMed:25194279}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs868438023  rs7164132  rs7169404  rs7169262 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:24718257}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19667759}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:29180244}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}.
Mouse PG classificationNA
click here to return to the previous page