| Gene Information | |
|---|---|
| Gene Name | ADAM11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 769 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000073670 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75078 |
| Gene Card | ADAM11 |
| Uniprot ID | O75078 |
| Pfam | PF08516; PF00200; PF07974; PF01562; PF01421 |
| In ASD | no |
| Allosteric Prediction | no (-0.946228966) |
| Ortholog in Animals | Alpaca_ ADAM11 ( ortholog_one2one ) Dog_ ADAM11 ( ortholog_one2one ) GuineaPig_ ADAM11 ( ortholog_one2one ) Macaque_ ADAM11 ( ortholog_one2one ) Mouse_ Adam11 ( ortholog_one2one ) Pig_ ADAM11 ( ortholog_one2one ) Rat_ Adam11 ( ortholog_one2one ) Rabbit_ ADAM11 ( ortholog_one2one ) |
| Ohnologs | ADAM22, ADAM28, ADAM7, ADAM2, ADAM23, ADAM19, ADAM9, ADAM18, ADAM32 |
| Paralogs | ADAM20, ADAM33, ADAM19, ADAM17, ADAM9, ADAM28, ADAM32, ADAM21, ADAM22, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8 |
| Tissue | brain, heart, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed predominantly in brain. Slightly detected or not at all in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4}. |
| Mouse PG classification | NA |
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