| Gene Information | |
|---|---|
| Gene Name | SLCO2B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 709 |
| Protein Names | Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) |
| Target Name | organic anion transporter b |
| Target Type | Literature-reported target |
| Gene Age | 244 ( ENSG00000137491 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94956 |
| Gene Card | SLCO2B1 |
| Uniprot ID | O94956 |
| Pfam | PF03137 |
| In ASD | no |
| Allosteric Prediction | yes (0.525377664) |
| Ortholog in Animals | Alpaca_ SLCO2B1 ( ortholog_one2one ) Dog_ SLCO2B1 ( ortholog_one2one ) GuineaPig_ SLCO2B1 ( ortholog_one2one ) Macaque_ SLCO2B1 ( ortholog_one2one ) Mouse_ Slco2b1 ( ortholog_one2one ) Pig_ SLCO2B1 ( ortholog_one2one ) Rat_ Slco2b1 ( ortholog_one2one ) Rabbit_ SLCO2B1 ( ortholog_one2one ) |
| Ohnologs | SLCO1A2, SLCO1C1, SLCO2A1 |
| Paralogs | SLCO5A1, SLCO6A1, SLCO4C1, SLCO4A1, SLCO2A1, SLCO1B1, SLCO1B3, SLCO1C1, SLCO1A2, SLCO3A1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in the liver, at the sinusoidal membrane of the hepatocytes (PubMed:10873595, PubMed:11159893, PubMed:23531488). Expressed in the kidney (PubMed:11159893). Expressed in placental trophoblasts and syncytiotrophoblast (PubMed:11159893, PubMed:11932330, PubMed:12409283, PubMed:26277985). Expressed in the small intestine (PubMed:10873595, PubMed:11159893, PubMed:12724351, PubMed:23531488). Expressed in the blood-brain barrier, in endothelial cells of brain capillaries (PubMed:11159893, PubMed:25132355). Expressed in the retina, in the inner nuclear layer and the inner plexiform layer (PubMed:25132355). Expressed in skelettal muscles (PubMed:23531488). Expressed in pancreas, lung, heart, colon, ovary, testis and spleen (PubMed:10873595, PubMed:11159893). Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas (PubMed:10873595). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985}.; [Isoform 1]: Highest expression in brain. Predominant isoform compared to isoform 3 in small intestine duodenum, kidney, placenta, and skeletal muscle. {ECO:0000269|PubMed:23531488}.; [Isoform 3]: Predominant isoform compared to isoform 1 in liver. Also expressed in small intestine duodenum, kidney, brain, placenta, and skeletal muscle. {ECO:0000269|PubMed:23531488}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs865987804 rs35199625 rs12422149 rs1621378 rs2306168 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25132355}; Multi-pass membrane protein. Basal cell membrane {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:12724351}; Multi-pass membrane protein. Note=Expressed at the basal membrane of the hepatocytes and syncytiotrophoblast (PubMed:11159893, PubMed:11932330, PubMed:12409283). Expressed at the apical membrane of intestinal cells (PubMed:12724351). {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351}. |
| Mouse PG classification | NA |
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