| Gene Information | |
|---|---|
| Gene Name | GPR143 |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | G-protein coupled receptor 143 (Ocular albinism type 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000101850 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51810 |
| Gene Card | GPR143 |
| Uniprot ID | P51810 |
| Pfam | PF02101 |
| In ASD | no |
| Allosteric Prediction | yes (0.419581554) |
| Ortholog in Animals | Alpaca_ GPR143 ( ortholog_one2one ) GuineaPig_ GPR143 ( ortholog_one2one ) Macaque_ GPR143 ( ortholog_one2one ) Mouse_ Gpr143 ( ortholog_one2one ) Rat_ Gpr143 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland. {ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:7647783}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs62635289 rs62635018 rs62635019 rs62635024 rs62635025 rs62635027 rs62635026 rs137852298 rs62635030 rs62635029 rs62635031 rs62635032 rs137852296 rs62635762 rs58933950 rs62635035 rs199899645 rs62635037 rs137852297 rs62635038 rs62635040 rs62635043 rs62635044 rs62635046 rs62635045 |
| Subcellular location [CC] | Melanosome membrane {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:16621890, ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:16621890}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18828673}; Multi-pass membrane protein {ECO:0000255}. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673). {ECO:0000269|PubMed:18828673}. |
| Mouse PG classification | HPG |
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