| Gene Information | |
|---|---|
| Gene Name | GPR132 |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Probable G-protein coupled receptor 132 (G2 accumulation protein) |
| Target Name | g2 accumulation protein |
| Target Type | Literature-reported target |
| Gene Age | 12 ( ENSG00000183484 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UNW8 |
| Gene Card | GPR132 |
| Uniprot ID | Q9UNW8 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.547989784) |
| Ortholog in Animals | GuineaPig_ GPR132 ( ortholog_one2one ) Rat_ Gpr132 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | P2RY11, GPR183, GPR174, GPR141, GPR146, RXFP3, GPR151 |
| Tissue | appendix, lymph.node, spleen |
| Tissue Specificity | Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. {ECO:0000269|PubMed:12482833}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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