| Gene Information | |
|---|---|
| Gene Name | GPR129 |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5NUL3 |
| Gene Card | FFAR4 |
| Uniprot ID | Q5NUL3 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipocytes of white adipose tissue (at protein level) (PubMed:31761534). {ECO:0000269|PubMed:24742677, ECO:0000269|PubMed:31761534}.; Abundant expression in the intestinal tract. Expressed in colonic intraepithelial neuroendocrine cells. {ECO:0000269|PubMed:15619630}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs61866610 rs116454156 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Note=Sorted to late endosome/lysosome compartments upon internalization. {ECO:0000269|PubMed:22282525}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:22282525}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000305|PubMed:31761534}; Multi-pass membrane protein {ECO:0000255}. Note=Sorted to late endosome/lysosome compartments upon internalization (PubMed:22282525). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3-dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (Probable). {ECO:0000269|PubMed:22282525, ECO:0000305|PubMed:31761534}. |
| Mouse PG classification | NA |
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