| Gene Information | |
|---|---|
| Gene Name | SUZ12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 739 |
| Protein Names | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000178691 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15022 |
| Gene Card | SUZ12 |
| Uniprot ID | Q15022 |
| Pfam | PF09733 |
| In ASD | no |
| Allosteric Prediction | yes (0.428445059) |
| Ortholog in Animals | Alpaca_ SUZ12 ( ortholog_one2one ) Alpaca_ SUZ12 ( ortholog_one2many ) Dog_ SUZ12 ( ortholog_one2one ) GuineaPig_ SUZ12 ( ortholog_one2one ) Macaque_ SUZ12 ( ortholog_one2one ) Mouse_ Suz12 ( ortholog_one2one ) Pig_ SUZ12 ( ortholog_one2one ) Rat_ Suz12 ( ortholog_one2one ) Rabbit_ SUZ12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.055556(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4W2R (X-ray 2.81A ) 5HYN (X-ray 2.95A ) 5IJ7 (X-ray 2.62A ) 5IJ8 (X-ray 2.99A ) 5LS6 (X-ray 3.47A ) 5WAI (X-ray 2.90A ) 5WAK (X-ray 3.20A ) 5WG6 (X-ray 3.90A ) 6B3W (X-ray 3.05A ) 6C23 (EM 3.90A ) 6C24 (EM 3.50A ) 6NQ3 (X-ray 2.89A ) 6WKR (EM 3.50A ) 7AT8 (EM 4.40A ) 7KSO (EM 3.90A ) 7KSR (EM 4.10A ) 7KTP (EM 4.80A ) |
| DBSNP | rs17339444 rs1567840381 rs1598192095 rs1131692177 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Mouse PG classification | NA |
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