| Gene Information | |
|---|---|
| Gene Name | GPM6A |
| Organism | Homo sapiens (Human) |
| Gene Length | 278 |
| Protein Names | Neuronal membrane glycoprotein M6-a (M6a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000150625 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51674 |
| Gene Card | GPM6A |
| Uniprot ID | P51674 |
| Pfam | PF01275 |
| In ASD | no |
| Allosteric Prediction | no (-0.840212638) |
| Ortholog in Animals | Alpaca_ GPM6A ( ortholog_one2one ) Dog_ GPM6A ( ortholog_one2one ) GuineaPig_ GPM6A ( ortholog_one2one ) Macaque_ GPM6A ( ortholog_one2one ) Mouse_ Gpm6a ( ortholog_one2one ) Pig_ GPM6A ( ortholog_one2one ) Rat_ Gpm6a ( ortholog_one2one ) Rabbit_ GPM6A ( ortholog_one2one ) |
| Ohnologs | GPM6B, PLP1 |
| Paralogs | GPM6B, PLP1 |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1049820 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P35802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35802}. Cell projection, axon {ECO:0000250|UniProtKB:P35802}. Cell projection, growth cone {ECO:0000250|UniProtKB:P35802}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q812E9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q812E9}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q812E9}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250|UniProtKB:P35802, ECO:0000250|UniProtKB:Q812E9}. |
| Mouse PG classification | NA |
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