| Gene Information | |
|---|---|
| Gene Name | WWTR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000018408 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9GZV5 |
| Gene Card | WWTR1 |
| Uniprot ID | Q9GZV5 |
| Pfam | PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.209783484) |
| Ortholog in Animals | Alpaca_ WWTR1 ( ortholog_one2one ) Dog_ WWTR1 ( ortholog_one2one ) GuineaPig_ WWTR1 ( ortholog_one2one ) Macaque_ WWTR1 ( ortholog_one2one ) Mouse_ Wwtr1 ( ortholog_one2one ) Pig_ WWTR1 ( ortholog_one2one ) Rat_ Wwtr1 ( ortholog_one2one ) Rabbit_ WWTR1 ( ortholog_one2one ) |
| Ohnologs | YAP1 |
| Paralogs | YAP1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001425(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 5N5R (X-ray 1.80A ) 5N5T (X-ray 1.80A ) 5N5W (X-ray 1.37A ) 5N75 (X-ray 1.80A ) 6RHC (X-ray 1.20A ) 6RJL (X-ray 1.28A ) 6RJQ (X-ray 1.89A ) 6RP6 (X-ray 1.89A ) 6SLW (X-ray 2.00A ) 6SLX (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:25849865}. Cytoplasm {ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:25849865}. Cell membrane {ECO:0000269|PubMed:11118213}. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). {ECO:0000250|UniProtKB:Q9EPK5, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:21145499}. |
| Mouse PG classification | NA |
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