Gene Information
Gene NameGPHN
OrganismHomo sapiens (Human)
Gene Length736
Protein NamesGephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]
Target Namegephyrin
Target TypeNA
Gene Age454 ( ENSG00000171723 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9NQX3
Gene CardGPHN
Uniprot IDQ9NQX3
PfamPF00994; PF03454; PF03453
In ASDno
Allosteric Predictionyes (0.781743457)
Ortholog in AnimalsAlpaca_ GPHN ( ortholog_one2one )
Dog_ GPHN ( ortholog_one2one )
GuineaPig_ GPHN ( ortholog_one2one )
Macaque_ GPHN ( ortholog_one2one )
Mouse_ Gphn ( ortholog_one2one )
Pig_ GPHN ( ortholog_one2one )
Rat_ Gphn ( ortholog_one2many )
Rabbit_ GPHN ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1JLJ  (X-ray  1.60A  ) 
DBSNP rs121908539  rs397518420 
Subcellular location [CC]Postsynaptic cell membrane {ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940};
Lipid-anchor {ECO:0000269|PubMed:25025157};
Cytoplasmic side {ECO:0000305|PubMed:25025157}. Cell membrane {ECO:0000250|UniProtKB:Q03555};
Lipid-anchor {ECO:0000250|UniProtKB:Q03555};
Cytoplasmic side {ECO:0000250|UniProtKB:Q03555}. Cytoplasm, cytosol {ECO:0000269|PubMed:25025157}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03555}. Cell projection, dendrite {ECO:0000269|PubMed:26613940}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BUV3}. Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity). Forms clusters at synapses (PubMed:25025157). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157}.
Mouse PG classificationNA
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