| Gene Information | |
|---|---|
| Gene Name | BAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 729 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163930 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92560 |
| Gene Card | BAP1 |
| Uniprot ID | Q92560 |
| Pfam | PF01088; PF18031 |
| In ASD | no |
| Allosteric Prediction | yes (0.420081545) |
| Ortholog in Animals | Alpaca_ BAP1 ( ortholog_one2one ) Dog_ SEMA3G ( ortholog_one2one ) GuineaPig_ BAP1 ( ortholog_one2one ) Macaque_ BAP1 ( ortholog_one2one ) Mouse_ Bap1 ( ortholog_one2one ) Pig_ BAP1 ( ortholog_one2one ) Rat_ Bap1 ( ortholog_one2one ) Rabbit_ BAP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UCHL1, UCHL3, UCHL5 |
| Tissue | substantia.nigra |
| Tissue Specificity | Highly expressed in testis, placenta and ovary. Expressed in breast. {ECO:0000269|PubMed:9528852}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002166(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs747311942 rs149974450 rs35353781 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:24748658, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:9528852}. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269|PubMed:24703950}. |
| Mouse PG classification | NA |
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