| Gene Information | |
|---|---|
| Gene Name | GPC6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 555 |
| Protein Names | Glypican-6 [Cleaved into: Secreted glypican-6] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000183098 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y625 |
| Gene Card | GPC6 |
| Uniprot ID | Q9Y625 |
| Pfam | PF01153 |
| In ASD | no |
| Allosteric Prediction | no (-0.643054388) |
| Ortholog in Animals | Alpaca_ GPC6 ( ortholog_one2one ) Dog_ GPC6 ( ortholog_one2one ) GuineaPig_ GPC6 ( ortholog_one2one ) Macaque_ GPC6 ( ortholog_one2one ) Mouse_ Gpc6 ( ortholog_one2one ) Pig_ GPC6 ( ortholog_one2one ) Rat_ Gpc6 ( ortholog_one2one ) Rabbit_ GPC6 ( ortholog_one2one ) |
| Ohnologs | GPC4, GPC3, GPC1, GPC2 |
| Paralogs | GPC4, GPC1, GPC2, GPC3, GPC5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level). {ECO:0000269|PubMed:10480909, ECO:0000269|PubMed:21871017}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1535692 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; [Secreted glypican-6]: Secreted, extracellular space {ECO:0000250}. |
| Mouse PG classification | NA |
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