| Gene Information | |
|---|---|
| Gene Name | GPC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 558 |
| Protein Names | Glypican-1 [Cleaved into: Secreted glypican-1] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000063660 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P35052 |
| Gene Card | GPC1 |
| Uniprot ID | P35052 |
| Pfam | PF01153 |
| In ASD | no |
| Allosteric Prediction | no (-0.060339959) |
| Ortholog in Animals | Alpaca_ GPC1 ( ortholog_one2one ) Dog_ GPC1 ( ortholog_one2one ) GuineaPig_ GPC1 ( ortholog_one2one ) Macaque_ GPC1 ( ortholog_one2one ) Mouse_ Gpc1 ( ortholog_one2one ) Pig_ GPC1 ( ortholog_one2one ) Rat_ Gpc1 ( ortholog_one2one ) |
| Ohnologs | GPC4, GPC3, GPC5, GPC6, GPC2 |
| Paralogs | GPC4, GPC6, GPC2, GPC3, GPC5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ACR (X-ray 2.55A ) 4AD7 (X-ray 2.94A ) 4BWE (X-ray 2.46A ) 4YWT (X-ray 2.38A ) |
| DBSNP | rs2228331 |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; [Secreted glypican-1]: Secreted, extracellular space. |
| Mouse PG classification | NA |
| click here to return to the previous page | |