Gene Information
Gene NameTRIP4
OrganismHomo sapiens (Human)
Gene Length581
Protein NamesActivating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000103671 )
Evolutionary StageEukaryota
AlphaFoldDBQ15650
Gene CardTRIP4
Uniprot IDQ15650
PfamPF04266; PF06221
In ASDno
Allosteric Predictionno (-0.976602171)
Ortholog in AnimalsAlpaca_ TRIP4 ( ortholog_one2one )
Dog_ TRIP4 ( ortholog_one2one )
GuineaPig_ TRIP4 ( ortholog_one2one )
Macaque_ TRIP4 ( ortholog_one2one )
Mouse_ Trip4 ( ortholog_one2one )
Pig_ TRIP4 ( ortholog_one2one )
Rat_ Trip4 ( ortholog_one2one )
Rabbit_ TRIP4 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.060652(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2E5O  (NMR 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:26924529}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}.
Mouse PG classificationNA
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