Gene Information
Gene NameSCN10A
OrganismHomo sapiens (Human)
Gene Length1956
Protein NamesSodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
Target Namevoltage-gated sodium channel alpha nav1.8
Target TypeSuccessful target
Gene Age680 ( ENSG00000185313 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y5Y9
Gene CardSCN10A
Uniprot IDQ9Y5Y9
PfamPF00520; PF06512
In ASDyes
Allosteric Predictionyes (1.296208777)
Ortholog in AnimalsAlpaca_ SCN10A ( ortholog_one2one )
Dog_ SCN10A ( ortholog_one2one )
GuineaPig_ SCN10A ( ortholog_one2one )
Macaque_ SCN10A ( ortholog_one2one )
Mouse_ Scn10a ( ortholog_one2one )
Pig_ SCN10A ( ortholog_one2one )
Rat_ Scn10a ( ortholog_one2one )
Rabbit_ SCN10A ( ortholog_one2one )
OhnologsSCN4A, SCN8A, SCN2A, SCN7A, SCN1A, SCN3A, SCN9A
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
TissueNA
Tissue SpecificityExpressed in the dorsal root ganglia and sciatic nerve. {ECO:0000269|PubMed:9839820}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7WE4  (EM  2.70A  )  7WEL  (EM  3.20A  )  7WFR  (EM  3.00A  )  7WFW  (EM  3.10A  ) 
DBSNP rs7630989  rs138404783  rs35332705  rs370208223  rs202174472  rs751574392  rs6795970  rs12632942  rs142173735  rs142217269  rs151090729  rs6599241 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:D0E0C2};
Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000250}.
Mouse PG classificationNA
click here to return to the previous page