| Gene Information | |
|---|---|
| Gene Name | PTPRH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1115 |
| Protein Names | Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000080031 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HD43 |
| Gene Card | PTPRH |
| Uniprot ID | Q9HD43 |
| Pfam | PF00041; PF00102 |
| In ASD | no |
| Allosteric Prediction | no (-0.434376669) |
| Ortholog in Animals | Alpaca_ PTPRH ( ortholog_one2one ) Dog_ PTPRH ( ortholog_one2one ) Macaque_ PTPRH ( ortholog_one2one ) Mouse_ Ptprh ( ortholog_one2one ) Pig_ PTPRH ( ortholog_one2one ) Rat_ Ptprh ( ortholog_one2one ) |
| Ohnologs | PTPRB |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPN21 |
| Tissue | gall.bladder, adrenal.gland, small.intestine.Peyers.patch, spleen, stomach, transverse.colon |
| Tissue Specificity | Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness. {ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:12879010, ECO:0000269|PubMed:8294459}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7XC0 (X-ray 1.56A ) |
| DBSNP | rs55870162 rs45535035 rs2288515 rs16986309 rs2288523 rs890870 rs36092369 rs2288419 |
| Subcellular location [CC] | Cell projection, microvillus membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:E9Q0N2}. |
| Mouse PG classification | NA |
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