| Gene Information | |
|---|---|
| Gene Name | GP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | Platelet glycoprotein VI (GPVI) (Glycoprotein 6) |
| Target Name | platelet glycoprotein vi |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000088053 ) 3 ( ENSG00000274050 ) 3 ( ENSG00000274566 ) 3 ( ENSG00000275633 ) 3 ( ENSG00000275931 ) 3 ( ENSG00000276065 ) 3 ( ENSG00000276211 ) 3 ( ENSG00000277439 ) 3 ( ENSG00000278316 ) 3 ( ENSG00000278670 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HCN6 |
| Gene Card | GP6 |
| Uniprot ID | Q9HCN6 |
| Pfam | PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-0.197770787) |
| Ortholog in Animals | Alpaca_ GP6 ( ortholog_one2one ) Dog_ GP6 ( ortholog_one2one ) Macaque_ GP6 ( ortholog_one2many ) Mouse_ Gp6 ( ortholog_one2one ) Rat_ Gp6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KIR2DL3, KIR3DL3, KIR3DL2, LILRB2, KIR3DL1, KIR2DS4, LILRB5, KIR2DL4, LILRA2, LILRA4, LILRA6, LILRA5, NCR1, LILRB4, LILRB1, FCAR, LILRA1, LILRB3, KIR2DL1, IGSF1, OSCAR, TARM1, VSTM1, LAIR2, A1BG |
| Tissue | NA |
| Tissue Specificity | Megakaryocytes and platelets. {ECO:0000269|PubMed:10961879}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GI7 (X-ray 2.40A ) 5OU7 (X-ray 1.90A ) 5OU8 (X-ray 2.50A ) 5OU9 (X-ray 2.50A ) 7NMU (X-ray 2.50A ) |
| DBSNP | rs199588110 rs387906919 rs1613662 rs1654416 rs2304167 rs1654413 rs1671152 rs1654412 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Cell membrane; Single-pass membrane protein. |
| Mouse PG classification | NA |
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