| Gene Information | |
|---|---|
| Gene Name | SCN2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 215 |
| Protein Names | Sodium channel subunit beta-2 |
| Target Name | sodium channel protein |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000149575 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60939 |
| Gene Card | SCN2B |
| Uniprot ID | O60939 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.145457788) |
| Ortholog in Animals | Alpaca_ SCN2B ( ortholog_one2one ) Dog_ SCN2B ( ortholog_one2one ) GuineaPig_ SCN2B ( ortholog_one2one ) Macaque_ SCN2B ( ortholog_one2one ) Mouse_ Scn2b ( ortholog_one2one ) Pig_ SCN2B ( ortholog_one2one ) Rat_ Scn2b ( ortholog_one2one ) Rabbit_ SCN2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCN4B, MPZL1, JAML, MPZ, MPZL3, MPZL2 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum, nucleus.accumbens |
| Tissue Specificity | Brain specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5FDY (X-ray 1.85A ) 5FEB (X-ray 1.35A ) 6J8E (EM 3.00A ) 6J8G (EM 3.20A ) 6J8H (EM 3.20A ) 6J8I (EM 3.20A ) 6J8J (EM 3.20A ) 6VRR (X-ray 1.45A ) 7W77 (EM 3.30A ) 7W7F (EM 3.35A ) 7W9K (EM 2.20A ) 7W9L (EM 3.50A ) 7W9M (EM 3.00A ) 7W9P (EM 2.90A ) 7W9T (EM 3.00A ) 7XVE (EM 2.70A ) 7XVF (EM 2.80A ) |
| DBSNP | rs72544145 rs17121819 rs17121818 rs587777023 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | LPG |
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