Gene Information
Gene NameGP2
OrganismHomo sapiens (Human)
Gene Length537
Protein NamesPancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)
Target NameNA
Target TypeNA
Gene Age55 ( ENSG00000169347 )
Evolutionary StageEumetazoa
AlphaFoldDBP55259
Gene CardGP2
Uniprot IDP55259
PfamPF00100
In ASDno
Allosteric Predictionno (-0.750112306)
Ortholog in AnimalsAlpaca_ GP2 ( ortholog_one2one )
Dog_ GP2 ( ortholog_one2one )
Macaque_ GP2 ( ortholog_one2one )
Mouse_ Gp2 ( ortholog_one2one )
Pig_ GP2 ( ortholog_one2one )
Rat_ Gp2 ( ortholog_one2one )
OhnologsNA
ParalogsZPLD1, TECTB, OIT3, UMODL1, UMOD
Tissuepancreas
Tissue SpecificityExpressed in pancreas (at protein level) (PubMed:8666297, PubMed:10760606). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495). {ECO:0000269|PubMed:10760606, ECO:0000269|PubMed:19907495, ECO:0000269|PubMed:8666297}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7P6R  (X-ray  1.90A  )  7P6S  (X-ray  1.35A  )  7P6T  (X-ray  1.40A  ) 
DBSNP NA 
Subcellular location [CC]Zymogen granule membrane {ECO:0000250|UniProtKB:P19218};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000305|PubMed:10760606}.
Mouse PG classificationNA
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