Gene Information
Gene NameSCN5A
OrganismHomo sapiens (Human)
Gene Length2016
Protein NamesSodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
Target Namevoltage-gated sodium channel alpha nav1.5
Target TypeSuccessful target
Gene Age382 ( ENSG00000183873 )
Evolutionary StageEukaryota
AlphaFoldDBQ14524
Gene CardSCN5A
Uniprot IDQ14524
PfamPF00520; PF06512; PF11933
In ASDno
Allosteric Predictionyes (1.804870786)
Ortholog in AnimalsAlpaca_ SCN5A ( ortholog_one2one )
Dog_ SCN5A ( ortholog_one2one )
GuineaPig_ SCN5A ( ortholog_one2one )
Macaque_ SCN5A ( ortholog_one2one )
Mouse_ Scn5a ( ortholog_one2one )
Pig_ SCN5A ( ortholog_one2one )
Rat_ Scn5a ( ortholog_one2one )
Rabbit_ SCN5A ( ortholog_one2one )
OhnologsSCN8A, SCN2A, SCN7A, SCN1A, SCN3A, SCN9A
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
Tissueheart, left.atrium, left.ventricle, pulmonary.valve, atrium
Tissue SpecificityFound in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. {ECO:0000269|PubMed:12358675}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2KBI  (NMR  -  )  2L53  (NMR  -  )  4DCK  (X-ray  2.20A  )  4DJC  (X-ray  1.35A  )  4JQ0  (X-ray  3.84A  )  4OVN  (X-ray  2.80A  )  5DBR  (X-ray  2.25A  )  6LQA  (EM  3.30A  )  6MUD  (X-ray  2.69A  )  7DTC  (EM  3.30A  )  7L83  (NMR  -  ) 
DBSNP rs199473043  rs41311087  rs199473044  rs199473045  rs199473551  rs6791924  rs199473046  rs199473047  rs199473048  rs199473553  rs199473049  rs199473050  rs199473051  rs199473052  rs199473053  rs199473054  rs199473055  rs199473554  rs199473055  rs199473056  rs199473057  rs199473058  rs199473556  rs199473059  rs185492581  rs199473557  rs199473060  rs199473061  rs199473062  rs199473062  rs199473063  rs199473065  rs199473066  rs199473067  rs199473558  rs199473559  rs199473070  rs199473070  rs41276525  rs45620037  rs45546039  rs199473560  rs199473071  rs199473072  rs199473561  rs199473074  rs45471994  rs199473076  rs199473077  rs199473078  rs199473079  rs199473080  rs199473081  rs199473562  rs199473082  rs199473083  rs61746118  rs199473084  rs199473563  rs199473086  rs137854608  rs199473087  rs199473088  rs199473564  rs199473090  rs199473091  rs199473092  rs199473093  rs199473094  rs199473095  rs199473095  rs199473096  rs199473565  rs199473097  rs28937318  rs28937318  rs199473098  rs199473099  rs199473566  rs199473100  rs199473101  rs199473567  rs199473102  rs199473103  rs199473104  rs199473105  rs199473107  rs199473108  rs199473568  rs199473109  rs72549410  rs199473569  rs199473110  rs199473111  rs761375502  rs199473570  rs199473112  rs199473113  rs199473571  rs41313697  rs199473114  rs199473572  rs199473115  rs199473116  rs144511230  rs199473117  rs199473118  rs137854606  rs41313691  rs45627438  rs199473120  rs199473573  rs199473121  rs199473122  rs3918389  rs1805124  rs199473124  rs199473125  rs199473576  rs199473126  rs36210423  rs184442491  rs36210423  rs199473127  rs199473128  rs199473130  rs199473131  rs199473132  rs12720452  rs45488304  rs199473133  rs199473577  rs199473134  rs199473135  rs199473578  rs199473136  rs199473137  rs185638763  rs45609733  rs199473138  rs199473579  rs41313681  rs199473139  rs199473140  rs199473141  rs199473142  rs199473143  rs199473144  rs199473580  rs199473145  rs45553235  rs199473147  rs199473148  rs199473149  rs199473150  rs137854611  rs137854611  rs199473582  rs199473152  rs199473153  rs199473154  rs199473156  rs199473157  rs199473158  rs199473159  rs199473160  rs199473584  rs199473162  rs199473164  rs199473166  rs199473586  rs199473167  rs199473168  rs199473587  rs199473169  rs199473170  rs199473171  rs199473172  rs199473173  rs199473174  rs199473175  rs199473588  rs199473176  rs199473177  rs199473589  rs199473178  rs199473179  rs137854605  rs199473590  rs199473180  rs199473181  rs199473181  rs61737825  rs199473591  rs41313667  rs137854609  rs137854609  rs199473183  rs199473185  rs199473592  rs763891399  rs199473186  rs45491996  rs137854617  rs199473593  rs199473187  rs199473188  rs199473189  rs199473190  rs1805125  rs199473191  rs199473192  rs7626962  rs199473193  rs199473194  rs199473195  rs199473196  rs199473197  rs199473199  rs199473594  rs41310765  rs41261344  rs199473202  rs794728920  rs199473597  rs199473204  rs199473205  rs199473598  rs199473206  rs199473207  rs199473208  rs199473210  rs199473211  rs199473599  rs199473213  rs45589741  rs199473600  rs199473214  rs137854616  rs199473601  rs137854618  rs199473216  rs199473217  rs41311127  rs199473218  rs28937319  rs199473603  rs41313031  rs199473219  rs199473220  rs199473221  rs28937317  rs199473222  rs199473224  rs199473224  rs199473225  rs199473604  rs199473226  rs199473227  rs199473228  rs199473229  rs199473230  rs199473231  rs199473232  rs199473233  rs199473234  rs199473235  rs199473236  rs199473237  rs199473608  rs199473239  rs199473239  rs199473609  rs199473240  rs137854612  rs199473610  rs199473241  rs199473242  rs199473611  rs199473244  rs199473612  rs199473245  rs199473246  rs199473247  rs199473248  rs199473249  rs199473250  rs199473251  rs199473613  rs199473252  rs199473253  rs199473614  rs199473254  rs199473255  rs199473256  rs199473257  rs199473615  rs199473258  rs199473259  rs199473616  rs199473260  rs199473261  rs199473262  rs199473263  rs199473264  rs199473265  rs199473266  rs199473267  rs199473268  rs137854602  rs199473617  rs199473269  rs199473270  rs199473618  rs199473271  rs199473619  rs199473273  rs199473274  rs1369632373  rs199473620  rs199473275  rs45514691  rs199473621  rs199473276  rs199473277  rs137854607  rs199473278  rs199473280  rs199473622  rs199473281  rs199473282  rs199473282  rs137854600  rs137854600  rs199473283  rs199473283  rs199473623  rs199473624  rs199473287  rs28937316  rs199473288  rs199473289  rs199473290  rs199473291  rs199473291  rs199473625  rs199473292  rs199473293  rs199473626  rs199473294  rs1060499900  rs199473295  rs199473627  rs199473297  rs199473297  rs137854604  rs199473298  rs199473628  rs199473299  rs199473300  rs199473302  rs193922726  rs199473303  rs199473304  rs199473629  rs199473305  rs199473307  rs199473308  rs199473631  rs199473309  rs199473310  rs199473632  rs199473311  rs199473314  rs199473634  rs137854601  rs199473316  rs199473317  rs727504495  rs137854614  rs137854615  rs137854619  rs79299226  rs199473635  rs137854610  rs199473320  rs45563942  rs199473321  rs794728898  rs199473322  rs199473636  rs199473323  rs199473324  rs45465995  rs199473325  rs199473325  rs864622270  rs150264233  rs199473326  rs199473327  rs199473328  rs137854603  rs199473637  rs199473329  rs199473330  rs41315493  rs41315493  rs199473331  rs199473638  rs199473333  rs199473639  rs199473334  rs199473335  rs199473336  rs41311117  rs41311117  rs45489199  rs199473640 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430};
Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P15389}. Cell junction {ECO:0000250|UniProtKB:P15389}. Note=RANGRF promotes trafficking to the cell membrane. Colocalizes with PKP2 at intercalated disks in the heart (By similarity). {ECO:0000250|UniProtKB:P15389, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23420830}.
Mouse PG classificationHPG
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