Gene Information
Gene NameEHMT1
OrganismHomo sapiens (Human)
Gene Length1298
Protein NamesHistone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000181090 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H9B1
Gene CardEHMT1
Uniprot IDQ9H9B1
PfamPF12796; PF13637; PF05033; PF00856
In ASDno
Allosteric Predictionyes (0.098443338)
Ortholog in AnimalsAlpaca_ EHMT1 ( ortholog_one2one )
Dog_ EHMT1 ( ortholog_one2one )
Macaque_ EHMT1 ( ortholog_one2one )
Mouse_ Ehmt1 ( ortholog_one2one )
Pig_ EHMT1 ( ortholog_one2one )
Rat_ Ehmt1 ( ortholog_one2one )
Rabbit_ EHMT1 ( ortholog_one2one )
OhnologsEHMT2
ParalogsKMT2B, ASH1L, NSD3, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD2, SETD1B, SETD1A, SUV39H2, KMT2D, NSD2, SETDB2, EZH2, KMT2C, NSD1, SETDB1
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:11347906}.
Pharmacological Animal Models0.000730(Chimpanzee);0.015233(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2IGQ  (X-ray  2.00A  )  2RFI  (X-ray  1.59A  )  3B7B  (X-ray  2.99A  )  3B95  (X-ray  2.99A  )  3FPD  (X-ray  2.40A  )  3HNA  (X-ray  1.50A  )  3MO0  (X-ray  2.78A  )  3MO2  (X-ray  2.49A  )  3MO5  (X-ray  2.14A  )  3SW9  (X-ray  3.05A  )  3SWC  (X-ray  2.33A  )  4I51  (X-ray  1.90A  )  5TTG  (X-ray  1.66A  )  5TUZ  (X-ray  1.95A  )  5V9J  (X-ray  1.74A  )  5VSD  (X-ray  1.85A  )  5VSF  (X-ray  1.70A  )  6BY9  (X-ray  2.30A  )  6MBO  (X-ray  1.59A  )  6MBP  (X-ray  1.95A  )  7T7M  (X-ray  2.85A  ) 
DBSNP rs79514677  rs11137198 
Subcellular location [CC]Nucleus. Chromosome. Note=Associates with euchromatic regions.
Mouse PG classificationNA
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